Paediatrics Publications
Document Type
Article
Publication Date
10-1-2014
Journal
British journal of clinical pharmacology
Volume
78
Issue
4
First Page
918
Last Page
928
URL with Digital Object Identifier
10.1111/bcp.12409
Abstract
AIMS: Population pharmacokinetic (pop PK) modelling can be used for PK assessment of drugs in breast milk. However, complex mechanistic modelling of a parent and an active metabolite using both blood and milk samples is challenging. We aimed to develop a simple predictive pop PK model for milk concentration-time profiles of a parent and a metabolite, using data on fluoxetine (FX) and its active metabolite, norfluoxetine (NFX), in milk.
COinS