Successful treatment of multiple angiomyolipomas with sirolimus in a child

Authors

K. Pabedinskas, London Health Sciences Centre
M. Kobrzynski, London Health Sciences Centre
G. Filler, London Health Sciences CentreFollow

Document Type

Article

Publication Date

5-1-2017

Journal

Indian Journal of Nephrology

Volume

27

Issue

3

First Page

237

Last Page

238

URL with Digital Object Identifier

10.4103/0971-4065.200520

Abstract

Tuberous sclerosis complex frequently results in the formation of renal angiomyolipomas (AMLs). Sirolimus (SIR) or everolimus can be used to treat large AMLs, although this treatment has rarely been described in children, particularly for multiple renal AMLs. A 15-year-old girl presented with bilateral severe chronic flank pain coinciding with increased renal size and hundreds of renal AMLs. We opted to treat her with SIR over the course of 3.5 years. Following her treatment, her renal size had substantially decreased and the AMLs had shrunk. The patient's pain subsided as well. Our case, which has never been described in published literature, demonstrates that a child with multiple renal AMLs can be treated with SIR, and suggests that this treatment may be a viable option for preventing the development of secondary morbidities such as chronic pain.