Paediatrics Publications
Document Type
Article
Publication Date
5-1-2013
Journal
Nature Reviews Molecular Cell Biology
Volume
14
Issue
5
First Page
297
Last Page
306
URL with Digital Object Identifier
10.1038/nrm3567
Abstract
Inactivation of the RB protein is one of the most fundamental events in cancer. Coming to a molecular understanding of its function in normal cells and how it impedes cancer development has been challenging. Historically, the ability of RB to regulate the cell cycle placed it in a central role in proliferative control, and research focused on RB regulation of the E2F family of transcription factors. Remarkably, several recent studies have found additional tumour-suppressor functions of RB, including alternative roles in the cell cycle, maintenance of genome stability and apoptosis. These advances and new structural studies are combining to define the multifunctionality of RB. © 2013 Macmillan Publishers Limited. All rights reserved.
