Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene

Authors

Charles A. Ishak, London Regional Cancer Program
Frederick A. Dick, London Regional Cancer ProgramFollow

Document Type

Article

Publication Date

1-2-2015

Journal

Molecular and Cellular Oncology

Volume

2

Issue

1

URL with Digital Object Identifier

10.4161/23723548.2014.968069

Abstract

Recent work demonstrates that retention of a single functional retinoblastoma susceptibility (RB1) allele is insufficient to maintain genome stability. Haploinsufficiency of RB1 accelerates cancer pathogenesis in concert with inactivation of tumor protein p53. Collectively, multiple lines of evidence suggest revision of the ‘2-hit’ model to include conditional haploinsufficiency of RB1.