Paediatrics Publications
Document Type
Article
Publication Date
1-2-2015
Journal
Molecular and Cellular Oncology
Volume
2
Issue
1
URL with Digital Object Identifier
10.4161/23723548.2014.968069
Abstract
Recent work demonstrates that retention of a single functional retinoblastoma susceptibility (RB1) allele is insufficient to maintain genome stability. Haploinsufficiency of RB1 accelerates cancer pathogenesis in concert with inactivation of tumor protein p53. Collectively, multiple lines of evidence suggest revision of the ‘2-hit’ model to include conditional haploinsufficiency of RB1.
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