Paediatrics Publications
Document Type
Article
Publication Date
7-1-2018
Journal
Nature Reviews Cancer
Volume
18
Issue
7
First Page
442
Last Page
451
URL with Digital Object Identifier
10.1038/s41568-018-0008-5
Abstract
The canonical model of RB-mediated tumour suppression developed over the past 30 years is based on the regulation of E2F transcription factors to restrict cell cycle progression. Several additional functions have been proposed for RB, on the basis of which a non-canonical RB pathway can be described. Mechanistically, the non-canonical RB pathway promotes histone modification and regulates chromosome structure in a manner distinct from cell cycle regulation. These functions have implications for chemotherapy response and resistance to targeted anticancer agents. This Opinion offers a framework to guide future studies of RB in basic and clinical research.
