Paediatrics Publications
Document Type
Article
Publication Date
6-1-2011
Journal
Journal of Cell Communication and Signaling
Volume
5
Issue
2
First Page
81
Last Page
83
URL with Digital Object Identifier
10.1007/s12079-011-0124-4
Abstract
Integrin-linked kinase (ILK) is a scaffolding protein with central roles in tissue development and homeostasis. Much debate has focused on whether ILK is a bona fide or a pseudo- kinase. This aspect of ILK function has been complicated by the large volumes of conflicting observations obtained from a wide variety of experimental approaches, from in vitro models, to analyses in invertebrates and in mammals. Key findings in support or against the notion that ILK is catalytically active are summarized. The importance of ILK as an adaptor protein is well established, and defining its role as a signaling hub will be the next key step to understand its distinct biological roles across tissues and species. © 2011 The International CCN Society.