Paediatrics Publications
Document Type
Article
Publication Date
10-26-2012
Journal
Journal of Biological Chemistry
Volume
287
Issue
44
First Page
37245
Last Page
37258
URL with Digital Object Identifier
10.1074/jbc.M112.366195
Abstract
Background: Aerobic glycolysis promotes resistance against Aβ toxicity. Results: Increased LDHA and PDK1 expression attenuates mitochondrial activity and confers resistance to Aβ. These proteins are down-regulated in a transgenic Alzheimer disease (AD) mouse model, and PDK1 is decreased in AD brain. Conclusion: PDK and LDHA are central mediators of Aβ resistance. Significance: Drugs that augment aerobic glycolysis may enhance brain cell survival in AD patients. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.