Role of MHC antigens and Immunoregulation in Graft Survival in autoimmunity

Authors

Bhagirath Singh, University of Western Ontario Faculty of Medicine & DentistryFollow

Document Type

Conference Proceeding

Publication Date

2007

Journal

Current Issues in Transplantation: Proceedings of the XVI Annual Conference of Indian Society of Organ Transplantation

Issue

Chapter 8

First Page

109

Last Page

114

Abstract

Using a syngeneic islet transplantation model system we have showed that in autoimmune type 1 diabetes transplanted islets are destroyed by the host immune system unless the transplanted islets lack class I major histocompatibility complex (MHC) molecules. Alternatively, immunomodulation of the host by induction of regulatory T cells prevented the destruction of autologous islet graft. We conclude that these approaches will allow successful transplantation of autologous islets derived from the host by stem cell or other technology without immunosuppression to reverse autoimmune type 1 diabetes.

Citation of this paper:

Singh B. Role of MHC antigens and Immunoregulation in Graft Survival. In Current Issues in Transplantation: Proceedings of the XVI Annual Conference of Indian Society of Organ Transplantation (ISOT-2005). Jaipur, Rajasthan, India. Ed. L.C. Sharma, Chapter 8, pp.109-114, 2007