Microbial adhesion to biomaterials and infections of the urogenital tract

Authors

G. Reid, Lawson Health Research Institute

Document Type

Conference Proceeding

Publication Date

1-1-2001

Journal

American Journal of Clinical Nutrition

Volume

73

Issue

2 SUPPL.

URL with Digital Object Identifier

10.1093/ajcn/73.2.437s

Abstract

The urogenital microflora of a healthy woman comprises ≈50 species of organisms, which differ in composition according to reproductive stages and exposure to several factors, including antibiotics and spermicides. Infections are very common with >300 million cases of urinary tract infections, bacterial vaginosis, and yeast vaginitis worldwide per annum. At the time of infection in the bladder and vagina, the urogenital flora is often dominated by the infecting pathogens, in contrast with healthy phases when indigenous organisms dominate. Premenopausal women have a flora of mostly lactobacilli, and certain properties of these strains, including adhesive ability and production of acids, bacteriocins, hydrogen peroxide, and biosurfactants, appear important in conferring protection to the host. Efforts to artificially restore an unbalanced flora with the use of probiotics have met with mixed results but research aimed at selecting scientifically based strains could well provide a reliable alternative treatment and preventive regimen to antibiotics in the future.