A preliminary assessment of Pseudomonas aeruginosa biofilm development using fluorescence spectroscopy

Authors

Yige Bao, West China School of Medicine/West China Hospital of Sichuan University
Blayne Welk, The University of Western Ontario
Gregor Reid, Lawson Health Research Institute
Jeremy P. Burton, The University of Western Ontario

Document Type

Article

Publication Date

7-1-2014

Journal

Novel Insights into Urinary Tract Infections and their Management

First Page

48

Last Page

59

URL with Digital Object Identifier

10.2217/FMEB2013.13.236

Abstract

Recurrent urinary tract infections are a widespread problem, particularly in women.Most episodes are caused by uropathogenic Escherichia coli. Reservoirs of these bacteria may not only reside at distant anatomical sites such as the intestinal tract, rectum, perineum and vagina, but also intracellularly within the bladder epithelia. Antimicrobial therapies used to treat primary urinary tract infections or prevent recurrences disrupt other bacteria in the distal urethra and vagina, and negate their ability to fend off the pathogens and prevent infection.