Family Medicine Publications
Document Type
Article
Publication Date
1-1-2020
Journal
Frontiers in Aging Neuroscience
Volume
12
First Page
22
Last Page
22
URL with Digital Object Identifier
10.3389/fnagi.2020.00022
Abstract
BACKGROUND: Multiple-modality exercise improves brain function. However, whether task-based brain functional connectivity (FC) following exercise suggests adaptations in preferential brain regions is unclear. The objective of this study was to explore memory function and task-related FC changes following multiple-modality exercise and mind-motor training in older adults with subjective cognitive complaints.
METHODS: We performed secondary analysis of memory function data in older adults [
RESULTS: Our findings indicated that the M4 group showed greater improvements in the Paired Associates tasks compared to the M2 group at 24 weeks [mean difference: 0.47, 95% confidence interval (CI): 0.08 to 0.86,
CONCLUSION: Our findings suggest that multiple modality exercise with mind-motor training resulted in greater improvements in memory compared to an active control group. There were divergent FC adaptations including significant decreased co-activation in the precentral/postcentral gyri during the Spatial Span task. Borderline significant changes during the Paired Associates tasks in FC provided insight into the potential of our intervention to promote improvements in visuospatial memory and impart FC adaptations in brain regions relevant to Alzheimer's disease risk.
CLINICAL TRIAL REGISTRATION: The trial was registered in ClinicalTrials.gov in April 2014, Identifier: NCT02136368.
