Does acute maximal exercise or chronic physical activity affect circulating angiotensin (1-9) concentrations?
Abstract
Introduction: Epidemiological evidence suggests physical inactivity can increase the likelihood of hospitalization from the SARS-COV-2 virus. Further, some data indicate a greater ratio of angiotensin 1-9 to angiotensin I helps prevent severe outcomes during infection. Moreover, related hormones can enhance potentially both physical activity and health. The purpose of this study was to determine whether plasma concentrations of angiotensin (1-9) are modified after a single exhaustive exercise bout and whether sex or chronic physical activity is associated with greater plasma concentrations.
Methods: Participants (n=14) performed a graded exercise test on a cycle ergometer. Antecubital area venipunctures were performed before, immediately following volitional fatigue, and after thirty minutes of recovery. Plasma was analyzed for angiotensin (1-9) using standard ELISA techniques.
Results: No significant changes in concentration of angiotensin (1-9) between time points or between sexes appeared. However, there was a significant correlation between quantity of weekly physical activity and concentration of angiotensin (1-9) immediately post exercise intervention. These results are likely affected by the changes in plasma volume with exercise and not from an increase in production of angiotensin (1-9).
Conclusion: There appears to be no obvious effect of a single dose of exhaustive exercise, sex, or the weekly accumulation of physical activity minutes on the circulating concentrations of angiotensin (1-9).