Sol-Gel Derived Bioceramic Poly(Diethyl Fumarate – Co – Triethoxyvinylsilane) Composite
Abstract
Synthetic bone graft materials have become an increasingly popular choice for bone augmentation. Ceramic-based and polymer-based bone graft materials constitute the two main classes of synthetic bone graft materials. This study investigated the synthesis of novel bioactive composites for their potential use as bone graft biomaterials. Poly(diethyl fumarate-co-triethoxyvinylsilane)/bioceramic class II organic/inorganic hybrid biomaterials were synthesized via a sol gel process. These biomaterials were then reacted with an ammonium phosphate solution to prepare their respective composites. For the first time, we successfully synthesized sol-gel derived bioceramic poly(diethyl fumarate-co-triethoxyvinylsilane) composites. In vitro bioactivity evaluation of poly(diethyl fumarate-co-triethoxyvinylsilane)/bioceramic composites in simulated body fluid exhibited hydroxyapatite surface formation. Mechanical testing revealed that these composites exhibit elastic moduli comparable to trabecular bone. Degradation of poly(diethyl fumarate-co-triethoxyvinylsilane)/bioceramic composites in phosphate buffer solution was controlled. It is necessary to conduct further research investigating cytotoxicity, cell attachment, proliferation and differentiation characteristics of these composites.