Mapping The Functional Organization of Human Frontoparietal Cortex With fMRI
Abstract
Higher-order cognitive functions, such as working memory, attention, and decision making, depend strongly on the functional integrity of frontal and parietal cortices. However, the internal workings of the frontoparietal network (FPN) are not well understood. A major contributor to this knowledge gap is our limited understanding of the intrinsic functional organization of the FPN. In order to address this gap, we examine task-dependent reconfigurations of functional connectivity (FC) within the FPN. We analyzed fMRI task-state data from 924 individuals from the Human Connectome Project Young Adult study. Our results show that FC within the FPN is highly stable across time within individuals. Furthermore, FC within the FPN is more consistent within than between individuals and more consistent within than between tasks. Overall, our findings indicate that human individuals exhibit a partially unique fine-grained functional organization within the FPN, and that this organization contains a task-specific component.