The Effects of Exercise Training on Indices of Cardiovascular Autonomic Neuropathy in STZ-Induced Type 1 Diabetic Rats Treated with Insulin
Abstract
This study investigated whether regular aerobic exercise training could prevent the dysregulation of autonomic cardiovascular (CV) control in a streptozotocin (STZ)-diabetes model designed to represent clinical type 1 diabetes mellitus (T1DM). Rats were divided into control (C), control exercise (CX), diabetic (D) and diabetic exercise (DX) groups. Baroreflex sensitivity (BRS), heart rate variability (HRV) and vascular sympathetic tone (VST) were measured following 10 weeks of exercise. Parasympathetic-mediated bradycardia BRS was reduced in D compared to C and DX (p
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