Fast spiking GABAergic interneurons in the dorsolateral prefrontal cortex of non-human primate: Comparison study to mice and human, with focus on subthreshold intrinsic properties
Abstract
Fast spiking (FS) parvalbumin expressing cells are one of the three major subpopulations of GABAergic interneurons. They generally show a consistent set of electrophysiological features across brain areas and species: short and narrow action potentials and capability of high frequency firing. This features are believed to be crucial for fast inhibition and generation of network oscillations associated with various cognitive phenomena. However, it is unclear whether other intrinsic properties of FS interneurons vary across species and/or brain areas. This study map out the subthreshold intrinsic properties of FS neurons of mouse, macaque and human. Features are derived from intracellular recordings of acute slices from two different databases (© 2018 Allen Brain Atlas: Allen Cell Type Database and NHP database from the Martinez Trujillo Laboratory). To classify FS interneurons in primates we developed a model based on parvalbumin specific mouse lines. Our results showed significant differences in almost all considered features. Primate neurons were more alike, having higher excitability and sag amplitude; however, between primates macaque cells reached higher values which may be due to differences in sampled brain region.