In-hospital Outcomes Following Left Atrial Appendage Closure
Abstract
Left atrial appendage closure (LAAC) is a non-pharmacologic approach for stroke prevention in patients with atrial fibrillation. The impact of comorbidity burden on adverse outcomes following LAAC is very important for clinical decision making. Cohort-based observational study was conducted to evaluate the association of comorbidity burden with in-hospital complications. Of 3294 participants (mean age was 75.7±8.2 years), 60% were male and 86% whites. The majority of participants undergoing LAAC presented with a significant number of comorbid conditions. The occurrence of in-hospital major adverse events (MAE) was 4.6%. Women and patients exhibiting higher Charlson Comorbidity Index (adjusted odds ratio [aOR]: 1.14, 95% confidence interval [CI]: 1.05-1.23, P=0.001), Elixhauser Comorbidity Score (aOR: 1.04, 95% CI: 1.02-1.07, P=0.002) and CHA2DS2-VASc (aOR: 1.11, 95% CI: 1.00-1.24, P=0.05) scores were associated with increased risk of in-hospital MAE after LAAC. Preprocedural comorbidity assessment is of paramount importance for risk stratification and further management of patients undergoing LAAC.