Individual Variability of Functional Connectivity in Resting-State and Naturalistic fMRI Paradigms
Abstract
Resting-state functional magnetic resonance imaging (fMRI) studies are criticized for their lack of control over cognitive states of individuals during observation, which may lead to increased variability in estimates of functional connectivity (FC). Engaging movies have been used in an attempt to synchronize the cognitive states of individuals during the scan, potentially reducing intersubject variability in connectivity estimates. The objective of this study was to investigate the differences in intersubject variability of FC between rest and movie conditions in a healthy cohort. The results demonstrate widespread reductions of intersubject variability of FC in the movie condition compared to the resting-state condition. These differences were pronounced in regions of the frontal, auditory, and visual cortex, suggesting effects on sensory areas as well as areas responsible for higher-order functioning. Because of its potential as a biomarker, less variable normative estimates of FC are beneficial for developing more sensitive tests for clinical use.