Electronic Thesis and Dissertation Repository

Degree

Master of Science

Program

Epidemiology and Biostatistics

Supervisor

Harris, Stewart B.

Abstract

Non-severe hypoglycemia (NSH) is a common, adverse event arising from the use of insulin/secretagogues to treat type 2 diabetes mellitus (T2DM). This thesis explored risk indicators for the frequency of any NSH, daytime NSH, and nocturnal NSH where outcomes were regarded as event counts and ordinal categories. Real-world data used in this thesis was provided by a population-based sample of Canadian adults with T2DM on insulin and/or secretagogues from the InHypo-DM Study. Count and ordinal outcomes were analyzed using negative binomial regression models and a proportional odds model, respectively. Backward selection was applied to both modelling approaches. Younger age, lower annual household income, being employed, longer duration of diabetes, higher HbA1c, having comorbidities were associated with an increased frequency of any NSH. Similar risk indicators were noted for daytime and nocturnal NSH. These findings may be used to identify patients at higher risk for NSH, creating opportunities to prevent hypoglycemia.

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