A Randomized Clinical Trial to Compare the Effect of Non Operative Treatment With and Without Autologous Conditioned Plasma (ACP) on Healing and Function in Patients with Achilles Tendon Ruptures

Author

Tyler M. Pratt, The University of Western OntarioFollow

Degree

Master of Science

Program

Health and Rehabilitation Sciences

Supervisor

Dr. Dianne Bryant

2nd Supervisor

Dr. Kevin Willits

Joint Supervisor

Abstract

The purpose of this study was to determine whether there is evidence to support conducting a larger randomized control trial (RCT) to compare the non-operative treatment of Achilles tendon (AT) ruptures with or without Autologous Conditioned Plasma (ACP®). Twenty-four patients were randomized to receive an ACP® or saline injection within seven days and again at two weeks post-rupture. Tendon healing was longitudinally evaluated using ultrasound (US) and magnetic resonance imaging (MRI). Functional and patient-reported quality of life measures were also assessed. A small sample size limited our ability to detect statistically significant differences. The mean rankings of healing were slightly higher in the ACP® group at most time points for MRI and US. Functional and patient-reported outcomes were also slightly higher in the ACP® group at most time points. The consistency of these preliminary results suggests that there is evidence to support conducting a larger RCT.

Recommended Citation

Pratt, Tyler M., "A Randomized Clinical Trial to Compare the Effect of Non Operative Treatment With and Without Autologous Conditioned Plasma (ACP) on Healing and Function in Patients with Achilles Tendon Ruptures" (2015). Electronic Thesis and Dissertation Repository. 3242.
https://ir.lib.uwo.ca/etd/3242