The Use of NP-110, a RHAMM Peptide Mimetic, Reduces Capsule Fibrosis in a Novel Rodent Model of Radiation-Induced Capsular Contracture
Abstract
Capsular contracture is a common complication of breast implant reconstructive surgery, which can be particularly devastating in the setting of post-mastectomy radiation. The objective of this thesis was to evaluate the effect of RHAMM function-blocking peptide mimetic NP-110 on a novel rodent model for radiation-induced capsular contracture. The model consisted of female rats who underwent surgery to place a 2cc silicone implant under the right fourth mammary fat pad. Animals received local injection of 100ug of NP-110 or scrambled control peptide followed by 26Gy of targeted ionizing radiation. Clinically, NP-110 treated animals showed decreased post-radiation fibrotic change. Masson’s trichrome and Picrosirius red stain showed significantly decreased collagen deposition and bundling in the NP-110 group (p