Interventions for preventing relapse or recurrence of major depressive disorder in adults in a primary care setting: a network meta-analysis

Authors

Andrew S. Moriarty, University of York
Lindsay Robertson, University of York
Faraz Mughal, Keele University, School of Medicine
Natalie Cook, Tees Esk and Wear Valleys NHS Foundation Trust
Simon Gilbody, University of York
Dean McMillan, University of York
Carolyn A. Chew-Graham, Keele University, School of Medicine
Shehzad Ali, University of York
Sarah E. Hetrick, Faculty of Medical and Health Sciences
Rachel Churchill, University of York
Nicholas Meader, University of York

Document Type

Article

Publication Date

11-15-2021

Journal

Cochrane Database of Systematic Reviews

Volume

2021

Issue

11

URL with Digital Object Identifier

10.1002/14651858.CD014832

Abstract

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. The aim is to assess, using network meta-analysis (NMA), the effectiveness and safety of interventions for preventing relapse-recurrence of depression in adults in a primary care setting. NMA is a technique for comparing three or more interventions simultaneously in a single analysis by combining both direct and indirect evidence across a network of studies. The objectives are to:. estimate the relative effectiveness of pharmacological, psychological and other interventions to prevent relapse-recurrence, compared with each other and controls (e.g. pill placebo, treatment as usual) on relapse-recurrence outcomes and adverse events; assess the effect of interventions on quality of life outcomes and social and occupational functioning; estimate the relative ranking of included interventions on relapse-recurrence, quality of life, and adverse events; summarise availability and principal findings of eligible economic evaluations.