Date of Award
2007
Degree Type
Thesis
Degree Name
Master of Science
Program
Medical Biophysics
Supervisor
Dr. Jerry Battista
Second Advisor
Prof. Jake Van Dyk.
Abstract
Commonly, the quality of treatment plans is judged using a dose-volume histogram (DVH). This study presents a novel technique for mapping normal tissue complication probabilities (NTCP) onto regions of dose-volume with considerations of risk. Simplified intensity modulated arc therapy (SIMAT) for treatment of the prostate was the technique used and the resulting NTCP values were mapped for complications in the rectum. The method implemented an algorithm that simulates a set of DVH curves via random walks through dose-volume space, guided by a clinical DVH base set. Dose volume space was represented by discrete grid points each of which had an associated NTCP spectrum for curves passing to the above-right. A NTCP tolerance value was selected for the map and the risk of violating this tolerance was identified in regions of dose-volume space. The generated maps distinguish high risk regions, and provide a technique-specific visualization tool to help select safer treatment plans
Recommended Citation
Kupchak, Connor, "EXPERIENCE DRIVEN DOSE-VOLUME HISTOGRAM MAPS OF NTCP RISK AS AN AID FOR RADIATION TREATMENT PLAN SELECTION AND OPTIMIZATION" (2007). Digitized Theses. 5087.
https://ir.lib.uwo.ca/digitizedtheses/5087
