Date of Award


Degree Type


Degree Name

Master of Science


Medical Biophysics


Maria Drangova, Ph.D.

Second Advisor

David W. Holdsworth, Ph.D.

Third Advisor

Ian A. Cunningham, Ph.D.


Objective: To develop and characterize a technique for optimizing image quality in retrospectively gated micro-computed tomography (micro-CT) images of mice caused by insufficient and irregular angular sampling. Materials and Methods: A least error sorting technique was developed where, for each angular position, the projection acquired closest to the desired cardiac phase is used to reconstruct a volumetric image. Images were acquired using a volumetric micro-CT scanner with a flat-panel detector mounted on a slip ring gantry. An acrylic edge phantom mimicking cardiac motion was used to characterize the system’s resolution. My findings were also demonstrated in a mouse model. Results: Measurements of resolution degradation caused by motion agreed well with predicted values. Compared to current methods, the least error technique showed a statistically significant improvement in systolic volume measurements (P = 0.0271). Conclusions: My least error technique effectively optimizes image quality in retrospectively gated micro-CT.



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