Date of Award
2008
Degree Type
Thesis
Degree Name
Master of Science
Program
Medical Biophysics
Supervisor
Maria Drangova, Ph.D.
Second Advisor
David W. Holdsworth, Ph.D.
Third Advisor
Ian A. Cunningham, Ph.D.
Abstract
Objective: To develop and characterize a technique for optimizing image quality in retrospectively gated micro-computed tomography (micro-CT) images of mice caused by insufficient and irregular angular sampling. Materials and Methods: A least error sorting technique was developed where, for each angular position, the projection acquired closest to the desired cardiac phase is used to reconstruct a volumetric image. Images were acquired using a volumetric micro-CT scanner with a flat-panel detector mounted on a slip ring gantry. An acrylic edge phantom mimicking cardiac motion was used to characterize the system’s resolution. My findings were also demonstrated in a mouse model. Results: Measurements of resolution degradation caused by motion agreed well with predicted values. Compared to current methods, the least error technique showed a statistically significant improvement in systolic volume measurements (P = 0.0271). Conclusions: My least error technique effectively optimizes image quality in retrospectively gated micro-CT.
Recommended Citation
Armitage, Stephen E.J., "Retrospectively Gated Computed Tomography in Mice" (2008). Digitized Theses. 4729.
https://ir.lib.uwo.ca/digitizedtheses/4729