Date of Award

2008

Degree Type

Thesis

Degree Name

Master of Science

Program

Biology

Supervisor

Dr. Rima Menassa

Second Advisor

Dr. Susanne Kohalmi

Third Advisor

Dr. Mark Bernards

Abstract

The accumulating body of research over the past two decades suggests that plant cell culture is an economically viable system for the production of protein based drugs. In an effort to investigate alternate routes of protein accumulation, interleukin-10 directed by its native signal peptide was fused to various tags including green fluorescent protein, Strepll and elastin-like polypeptide for the purpose of secretion into a culture medium. Our data suggest that media supplemented with several protein stabilizing agents enhanced the accumulation of secreted interleukin-10. It was also noted that the passage of IL-10 fusions through the cell wall into the extracellular media is limited to a cutoff of ~30 kDa. To elucidate the effect of ELP fusions on IL-10 trafficking and turnover, subcellular localization was performed via confocal analysis. IL-10- GFP-ELP targeted for secretion was found in the vacuoles rather than the apoplast, whereas an endoplasmic reticulum retained version of this construct resulted in the formation of numerous fluorescent protein bodies. The latter construct accumulated levels of IL-10 upwards of 2.4% TSP, 500-fold higher than the secreted identical protein. These results suggest that endoplasmic reticulum-retention is a more viable alternative for the production of plant recombinant IL-10 when compared to secretion.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.