Date of Award


Degree Type


Degree Name

Master of Science


Microbiology and Immunology


Dr. Gregor Reid


The aims of this thesis were to select probiotic bacteria with potential to confer anti-allergy effects, develop a food formulation to deliver the strains, then test the concept in humans. Lactobacillus rhamnosus GR-1 and Bifidobacterium adolescentis 7007-05 were selected and successfully incorporated into yogurt. A total of 95 subjects participated in three studies. Immunoglobulin, cytokine and chemokines proved to be poor markers for allergy. Subjects who consumed probiotic yogurt for two months during grass pollen season tended to have improvements in their symptoms and signs of allergy. This was not found during a similar study in the ragweed pollen season in 2007. In a randomized, placebo- controlled trial performed in Mwanza, Tanzania, Lactobacillus reuteri RC-14 and Lactobacillus rhamnosus GR-1 in capsule form were administered for 10 weeks to HIV-infected women. Treatment induced significant increases in CD4 ∞unts, but this was the only evidence for skewing towards a Th1 immune response.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.