Date of Award
2009
Degree Type
Thesis
Degree Name
Master of Science
Program
Epidemiology and Biostatistics
Supervisor
Dr. George Rodrigues
Abstract
Introduction: The objectives of this study were to assess the health-related quality-of-life
(HRQOL) and late toxicity effects of External Beam Radiation Therapy (EBRT) on prostate cancer (PC) patients treated with a hypofractionated course of EBRT (>73 Gy) and to further cross-validate the Prostate Cancer Radiation Toxicity (PCRT) questionnaire. Methods: A cross sectional study was performed using the EPIC (generic prostate HRQOL instrument), PCRT (specific prostate radiotherapy instrument HRQOL/late toxicity), and an unvalidated exit global HRQOL/late toxicity questionnaire. The initial sample size was calculated to be 276. Baseline variables of interest were abstracted from the medical recoreds.
Results: Response rate was 69 CA (190 participants). Mean age was 75.8 years (SD 5.5) and the mean time of questionnaire completion after radiotherapy was 852 days (SD 335 days). Mean scores for EPIC GU (85.1 SD 12.9), GI (84.1 SD 15.8), S (21.8 SD 20.7), and H (85.3 SD 13.7) as well as PCRT GU (66.1 SD 15.3), GI (83.6 SD 14.3), and S (39.4 SD 21.6) domains were calculated. We found significant associations between adverse effects on genitourinary tract and planning target volume-bladder overlap for PCRT GU domain scores. In comparison with the lower dose cohort no differences in GI/GU/S/H EPIC scores were observed.
Conclusion: Hypofractionated EBRT for PC resulted in excellent GI, and GU scores, and poor S scores. The PCRT domains continue to demonstrate construct/discriminant validity. The PCRT has the advantage of being a compact instrument providing normally distributed HRQOL GI/GU domain scores.
Recommended Citation
Eid, Somaya, "Health-Related Quality-of-Life Related to Hypofractionated Prostate Cancer Radiotherapy" (2009). Digitized Theses. 4104.
https://ir.lib.uwo.ca/digitizedtheses/4104