"THE IMPACT OF INTRA-ARTICULAR HYALURONIC ACID ON THE GAIT OF KNEE OSTE" by Joseph E. DeCaria

Date of Award

2009

Degree Type

Thesis

Degree Name

Master of Science

Program

Kinesiology

Supervisor

Dr. Robert Petrella

Abstract

The present study investigated the impact of intra-articular hyaluronic acid (HA) on the gait velocity of knee OA patients, along with patient pain, stiffness, and function. Thirty mild-moderate knee OA patients were randomized to receive three weekly injections of HA (2 ml of 20 mg/ml HA), or placebo (P) (1.2 ml of .001 mg/ml HA). Self-selected (SSGV) and fast (FGV) gait velocity were determined with the GAITRite system; self-reported pain, stiffness, and function were measured with the WOMAC OA Index; and overall patient function was determined with the six minute walk test. Data from one week, three months, and six months post-treatment was analyzed. At six months follow-up, SSGV was significantly improved in both the HA and P groups while only the HA group had significantly improved FGV. The effect of HA injections on knee OA patient gait velocity was not significantly different than P injections.

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