Date of Award


Degree Type


Degree Name

Master of Science


Medical Biophysics


Grace Parraga, Ph.D.


Metastatic disease is the most common cause of cancer-related deaths. Two established image analysis tools, the World Health Organization Handbook for Reporting Results for Cancer Treatment (2D measurement), and Response Evaluation Criteria in Solid Tumours (ID measurement), have been used to quantify metastatic tumour burden in vivo. Limitations of the ID and 2D measurements may be addressed using a 3D technique. The overall objective of this thesis was to determine the accuracy and reproducibility of a 3D measurement technique to be used as a potential imaging biomarker to quantify pulmonary metastases in vivo, using x-ray CT. We compared the accuracy and reproducibility of our 3D technique to the ID and 2D measurements using lung tumour phantoms of known dimensions and seven subjects with pulmonary metastases. Three­ dimensional measurements accurately quantified spherical and irregularly-shaped tumour phantoms (p<0.05), and most observers measurement patient metastases with high intra- and inter-observer reproducibility ICC>0.900.



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