Tissue Engineering Scaffolds for the Regeneration of Craniofacial Bone

Authors

Wailan D. Chan, University of Western Ontario
Hiran Perinpanayagam, University of Western Ontario
Harvey A. Goldberg, University of Western Ontario
Graeme K. Hunter, University of Western Ontario
S. Jeffrey Dixon, University of Western Ontario
Gildo C. Santos, University of Western OntarioFollow
Amin S. Rizkalla, University of Western Ontario

Document Type

Article

Publication Date

6-2009

Journal

Journal of the Canadian Dental Association

Volume

75

Issue

5

First Page

373

Last Page

377

Abstract

Current strategies for skeletal regeneration involve the use of autogenous and allogenic bone grafts that may not always be available or safe to use. One alternative is to develop materials for use as scaffolds for the tissue engineering of bone. We created architecturally nanofibrous scaffolds using the electrospinning technique. These calcium phosphate- based materials are porous, have a large surface-area-to-volume ratio and can be used to deliver drugs, biologics or cells for tissue engineering applications. Bone-matrix proteins were also conjugated to the surface of a polymer network of polycaprolactone and poly(2-hydroxyethyl methacrylate) to create a material with enhanced cellular responses. This biomimetic strategy resulted in favourable cell-surface interactions that will likely enhance bone-matrix synthesis and regeneration. These collective advancements enable the development of innovative scaffolds for applications in tissue engineering and bone regeneration.