Increased yields and simplified purification with a second-generation cobalt catalyst for the oxidative formation of trans-THF rings.

Authors

Cory Palmer
Nicholas A Morra
Andrew C Stevens
Barbora Bajtos
Ben P Machin
Brian L Pagenkopf

Document Type

Article

Publication Date

11-19-2009

Journal

Organic letters

Volume

11

Issue

24

First Page

5614

Last Page

5617

URL with Digital Object Identifier

10.1021/ol9023375

Abstract

The synthesis of a second-generation cobalt catalyst for the formation of trans-THF products via the Mukaiyama aerobic oxidative cyclization is reported. Two procedures have been developed with the new water-soluble catalyst that give superior yields and greatly simplify purification compared to the previous catalysts.