Chemistry Publications
Document Type
Article
Publication Date
6-15-2010
Journal
Organic letters
Volume
12
Issue
14
First Page
3168
Last Page
3171
URL with Digital Object Identifier
10.1021/ol101078z
Abstract
A new method for the synthesis of 5-azaindole derivatives is reported. A [3+2] dipolar cycloaddition between nitriles and a 3,4-cyclopropanopiperidine followed by SeO(2) oxidation affords the target compounds in moderate to excellent yields. The divergent nature and cost effectiveness of this method makes it very suitable for combinatorial applications in the pharmaceutical industry.
