Formal [4 + 2] cycloaddition of alkoxy-substituted donor-acceptor cyclobutanes and aldehydes catalyzed by Yb(OTf)3.

Authors

Mahmoud M Abd Rabo Moustafa
Andrew C Stevens
Ben P Machin
Brian L Pagenkopf

Document Type

Article

Publication Date

10-6-2010

Journal

Organic letters

Volume

12

Issue

21

First Page

4736

Last Page

4738

Abstract

The cycloaddition between 2-alkoxy-1,1-cyclobutane diesters and aromatic, heteroaromatic, or aliphatic aldehydes under Yb(OTf)(3) catalysis generates tetrahydropyrans in high yields with exclusive cis-stereochemistry.