Chemistry Publications
Document Type
Article
Publication Date
2-22-2011
Journal
Organic letters
Volume
13
Issue
6
First Page
1528
Last Page
1531
URL with Digital Object Identifier
10.1021/ol200220d
Abstract
The formal [4+3] cycloaddition of 2-alkoxy-1,1-dicarboxylate activated donor-acceptor cyclobutanes with nitrones is disclosed. The reaction forms structurally unique oxazepines in moderate to high yield with a wide scope of nitrones. In most cases either a diastereomeric mixture or a single diastereomer may be formed, depending on the reaction conditions.
