Chemistry Publications
Document Type
Article
Publication Date
2017
Journal
European Journal of Organic Chemistry
Abstract
Lewis acid promoted cycloaddition reactions of donoracceptor cyclopropanes are one of the well-studied approaches for the construction of heterocyclic and carbocyclic frameworks. During our efforts to exploit this strategy for the synthesis and functionalization of carbohydrate derived systems, we discovered the cycloaddition of nitriles with DA cyclopropanes. This personal account details our contributions to the development of this cycloaddition. The reaction discovery, methods development, and application in total synthesis along with relative examples from others has been discussed.
Notes
accepted for publication