Blue Fluorescent Deoxycytidine Analogues: Convergent Synthesis, Solid-state and Electronic Structure, and Solvatochromism

Authors

David W. Dodd, University of Western Ontario
Kalen N. Swanick, University of Western Ontario
Jacquelyn T. Price, University of Western Ontario
Allison L. Brazeau, University of Western Ontario
M. J. Ferguson, University of Alberta
Nathan D. Jones, University of Western Ontario
Robert H. E. Hudson, University of Western Ontario

Document Type

Article

Publication Date

2-7-2010

Journal

Organic & Biomolecular Chemistry

Volume

8

Issue

3

First Page

663

Last Page

666

URL with Digital Object Identifier

http://dx.doi.org/10.1039/b919921g

Abstract

We report the synthesis and photospectroscopic characterisation of intrinsically fluorescent triazole-appended cytidines. Fluorescence was found to be highly dependent on solvent conditions. X-Ray crystallographic data show the proton of the exocyclic amine of the nucleobase and the triazole N(3) engaged in a H-bond.