"Peptide Nucleic Acid Containing a Meta-Substituted Phenylpyrrolocytosi" by Filip Wojciechowski and Robert H. E. Hudson
 

Chemistry Publications

Peptide Nucleic Acid Containing a Meta-Substituted Phenylpyrrolocytosine Exhibits a Fluorescence Response and Increased Binding Affinity toward RNA

Document Type

Article

Publication Date

11-5-2009

Journal

Organic Letters

Volume

11

Issue

21

First Page

4878

Last Page

4881

URL with Digital Object Identifier

10.1021/ol9019474

Abstract

Peptide nucleic acids (PNA) containing meta-substituted 6-phenylpyrrolocytosine (PhpC), [mono-m-(aminoethoxy)phenyl]pyrrolocytosine (mmePhpC), [mono-m-(aminopropoxy)phenyl]pyrrolocytosine (mmpPhpC), and [mono-m-(guanidinoethoxy)phenyl]pyrrolocytosine (mmguaPhpC), have been synthesized. Meta-substituted PhpCs have been hybridized with overall higher binding affinity toward DNA and RNA than previously synthesized moePhpC or newly synthesized mopPhpC. The guanidinium-containing nucleobase, mmguaPhpC, exhibited the highest increase in binding affinity toward RNA while fluorometrically responding on the state of hybridization.

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