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This project will investigate cognition and cognitive fatigue in models of CNS autoimmunity. We will use automated touchscreens and fMRI to measure deficits in higher order brain functions.
We have two critical milestones in this project:
- to use touchscreen testing protocols to determine if mouse models demonstrate the same kinds of attention, working memory and cognitive fatigue deficits observed in MS, and
- to use fMRI to measure higher-order defects in the autoimmune models and identify any changes present that might be associated with cognitive dysfunction and the findings from human studies.
fMRI, Multiple sclerosis, Touchscreens