Title

Developing behavioural testing and MR imaging to evaluate cognitive impairment in models of CNS autoimmunity

Authors and Researchers

BrainsCAN, Western University
Steven Kerfoot, Western University
Sarah Morrow, Western University
Ravi Menon, Western University
Flavio Beraldo, Western University

Files

Description

This project will investigate cognition and cognitive fatigue in models of CNS autoimmunity. We will use automated touchscreens and fMRI to measure deficits in higher order brain functions.

We have two critical milestones in this project:

• to use touchscreen testing protocols to determine if mouse models demonstrate the same kinds of attention, working memory and cognitive fatigue deficits observed in MS, and
• to use fMRI to measure higher-order defects in the autoimmune models and identify any changes present that might be associated with cognitive dysfunction and the findings from human studies.

Publication Date

2018

Publisher

BrainsCAN

City

London

Keywords

fMRI, Multiple sclerosis, Touchscreens

Disciplines

Neurosciences

Funding

Funding Program

BrainsCAN Accelerator Grant: Stimulus

Additional BrainsCAN Support

Imaging Core,
Rodent Cognition Core

Notes

Western Faculty, Group or Institution

Department of Microbiology & Immunology, Schulich School of Medicine & Dentistry