Document Type
Article
Publication Date
2-6-2019
Journal
Journal of Neuroscience
Volume
39
Issue
6
First Page
1020
Last Page
1029
URL with Digital Object Identifier
10.1523/JNEUROSCI.2595-18.2018
Abstract
© 2019 the authors. The common marmoset (Callithrix jacchus) is a small New World primate species that has been recently targeted as a potentially powerful preclinical model of human prefrontal cortex dysfunction. Although the structural boundaries of frontal cortex were described in marmosets at the start of the 20th century (Brodmann, 1909) and refined more recently (Paxinos et al., 2012), the broad functional boundaries of marmoset frontal cortex have yet to be established. In this study, we sought to functionally derive boundaries of the marmoset lateral frontal cortex (LFC) using ultra-high field (9.4 T) resting-state functional magnetic resonance imaging (RS-fMRI). We collectedRS-fMRIdatainseven(fourfemales,threemales)lightlyanesthetizedmarmosetsandusedadata-drivenhierarchicalclustering approach to derive subdivisions of the LFC based on intrinsic functional connectivity. We then conducted seed-based analyses to assess the functional connectivity between these clusters and the rest of the brain. The results demonstrated seven distinct functional clusters withintheLFC.Thefunctionalconnectivitypatternsoftheseclusterswiththerestofthebrainwerealsofoundtobedistinctandorganized along a rostrocaudal gradient, consonant with those found in humans and macaques. Overall, these results support the view that marmosets are a promising preclinical modeling species for studying LFC dysfunction related to neuropsychiatric or neurodegenerative human brain diseases.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Notes
This article is available to copy, distribute, or display under the terms of the Creative Commons Attribution 4.0 International License (CC-BY). This license allows data and text mining, use of figures in presentations, and posting the article online, provided that the original article is credited.
The article was originally published as
Intrinsic functional boundaries of lateral frontal cortex in the common marmoset monkey. David J. Schaeffer, Kyle M. Gilbert, Joseph S. Gati, Ravi S. Menon and Stefan Everling. Journal of Neuroscience 6 February 2019, 39 (6) 1020-1029; DOI: https://doi.org/10.1523/JNEUROSCI.2595-18.2018