Document Type
Article
Publication Date
11-25-2020
Journal
Journal of Neuroscience
Volume
40
Issue
48
First Page
9236
Last Page
9249
URL with Digital Object Identifier
10.1523/JNEUROSCI.1984-20.2020
Abstract
Copyright © 2020 the authors Understanding the similarity of cortico-subcortical networks topologies between humans and nonhuman primate species is critical to study the origin of network alternations underlying human neurologic and neuropsychiatric diseases. The New World common marmoset (Callithrix jacchus) has become popular as a nonhuman primate model for human brain function. Most marmoset connectomic research, however, has exclusively focused on cortical areas, with connectivity to subcortical networks less extensively explored. Here, we aimed to first isolate patterns of subcortical connectivity with cortical resting-state networks in awake marmosets using resting-state fMRI, then to compare these networks with those in humans using connectivity fingerprinting. In this study, we used 5 marmosets (4 males, 1 female). While we could match several marmoset and human resting-state networks based on their functional fingerprints, we also found a few striking differences, for example, strong functional connectivity of the default mode network with the superior colliculus in marmosets that was much weaker in humans. Together, these findings demonstrate that many of the core cortico-subcortical networks in humans are also present in marmosets, but that small, potentially functionally relevant differences exist.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Notes
Copyright the authors. This article is available to copy, distribute, or display under the terms of the Creative Commons Attribution 4.0 International License (CC-BY). This license allows data and text mining, use of figures in presentations, and posting the article online, provided that the original article is credited.
Originally published as:
Cortico-Subcortical Functional Connectivity Profiles of Resting-State Networks in Marmosets and Humans. Yuki Hori, David J. Schaeffer, Atsushi Yoshida, Justine C. Cléry, Lauren K. Hayrynen, Joseph S. Gati, Ravi S. Menon, Stefan Everling. Journal of Neuroscience 25 November 2020, 40 (48) 9236-9249; DOI: 10.1523/JNEUROSCI.1984-20.2020