Hormone effects on fMRI and cognitive measures of encoding: Importance of hormone preparation

Authors

C. E. Gleason, University of Wisconsin-Madison
T. W. Schmitz, University of Wisconsin-Madison
T. Hess, University of Wisconsin-Madison
R. L. Koscik, University of Wisconsin-Madison
M. A. Trivedi, University of Wisconsin-Madison
M. L. Ries, University of Wisconsin-Madison
C. M. Carlsson, University of Wisconsin-Madison
M. A. Sager, University of Wisconsin-Madison
S. Asthana, University of Wisconsin-Madison
S. C. Johnson, University of Wisconsin-Madison

Document Type

Article

Publication Date

12-1-2006

Journal

Neurology

Volume

67

Issue

11

First Page

2039

Last Page

2041

URL with Digital Object Identifier

10.1212/01.wnl.0000247277.81400.43

Abstract

We compared fMRI and cognitive data from nine hormone therapy (HT)-naive women with data from women exposed to either opposed conjugated equine estrogens (CEE) (n = 10) or opposed estradiol (n = 4). Exposure to either form of HT was associated with healthier fMRI response; however, CEE-exposed women exhibited poorer memory performance than either HT-naive or estradiol-exposed subjects. These preliminary findings emphasize the need to characterize differential neural effects of various HTs. ©2006AAN Enterprises, Inc.

Notes

This is an author-accepted manuscript.

The publisher's version is available at:

Hormone effects on fMRI and cognitive measures of encoding: Importance of hormone preparation. C. E. Gleason, T. W. Schmitz, T. Hess, R. L. Koscik, M. A. Trivedi, M. L. Ries, C. M. Carlsson, M. A. Sager, S. Asthana, S. C. Johnson. Neurology Dec 2006, 67 (11) 2039-2041; DOI: 10.1212/01.wnl.0000247277.81400.43