Neuroplastic Sensorimotor Resting State Network Reorganization in Children With Hemiplegic Cerebral Palsy Treated With Constraint-Induced Movement Therapy.

Authors

Kathryn Y Manning, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
Ravi S Menon, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
Jan Willem Gorter, CanChild Centre for Childhood Disability Research, McMaster University and McMaster Children's Hospital, Hamilton, Ontario, Canada
Ronit Mesterman, CanChild Centre for Childhood Disability Research, McMaster University and McMaster Children's Hospital, Hamilton, Ontario, Canada
Craig Campbell, Department of Paediatrics and Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada
Lauren Switzer, Department of Paediatrics, University of Toronto, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada
Darcy Fehlings, Department of Paediatrics, University of Toronto, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, CanadaFollow

Document Type

Article

Publication Date

2-1-2016

Journal

Journal of child neurology

Volume

31

Issue

2

First Page

220

Last Page

226

URL with Digital Object Identifier

10.1177/0883073815588995

Abstract

Using resting state functional magnetic resonance imaging (MRI), we aim to understand the neurologic basis of improved function in children with hemiplegic cerebral palsy treated with constraint-induced movement therapy. Eleven children including 4 untreated comparison subjects diagnosed with hemiplegic cerebral palsy were recruited from 3 clinical centers. MRI and clinical data were gathered at baseline and 1 month for both groups, and 6 months later for the case group only. After constraint therapy, the sensorimotor resting state network became more bilateral, with balanced contributions from each hemisphere, which was sustained 6 months later. Sensorimotor resting state network reorganization after therapy was correlated with a change in the Quality of Upper Extremity Skills Test score at 1 month (r = 0.79, P = .06), and Canadian Occupational Performance Measure scores at 6 months (r = 0.82, P = .05). This clinically correlated resting state network reorganization provides further evidence of the neuroplastic mechanisms underlying constraint-induced movement therapy.

Notes

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