ON-OFF Effects of Dopaminergic Therapy on Psychiatric Symptoms in Parkinson's Disease.
Document Type
Article
Publication Date
1-1-2015
Journal
The Journal of neuropsychiatry and clinical neurosciences
Volume
27
Issue
2
First Page
134
Last Page
139
URL with Digital Object Identifier
10.1176/appi.neuropsych.14030055
Abstract
Psychiatric manifestations of Parkinson's disease (PD) are a cause of significant disability and the impact of dopaminergic medications is unclear. Using standardized rating scales, the authors tested the hypothesis that anxiety, depression, and apathy vary in the ON versus OFF states in PD in 33 PD patients and 29 healthy age- and education-matched controls. PD patients had significantly higher anxiety, depression, and apathy scores than control participants, regardless of ON-OFF state. Anxiety scores were higher in PD patients on relative to off dopaminergic medication. The ON-OFF difference in anxiety related to degree of improvement in motor function but not illness duration.
Notes
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