Correlation between resting state fMRI total neuronal activity and PET metabolism in healthy controls and patients with disorders of consciousness.

Authors

Andrea Soddu
Francisco Gómez
Lizette Heine
Carol Di Perri
Mohamed Ali Bahri
Henning U Voss
Marie-Aurélie Bruno
Audrey Vanhaudenhuyse
Christophe Phillips
Athena Demertzi
Camille Chatelle
Jessica Schrouff
Aurore Thibaut
Vanessa Charland-Verville
Quentin Noirhomme
Eric Salmon
Jean-Flory Luaba Tshibanda
Nicholas D Schiff
Steven Laureys

Document Type

Article

Publication Date

1-1-2016

Journal

Brain Behav

Volume

6

Issue

1

First Page

00424

Last Page

00424

URL with Digital Object Identifier

https://doi.org/10.1002/brb3.424

Abstract

INTRODUCTION: The mildly invasive 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure 'resting state' cerebral metabolism. This technique made it possible to assess changes in metabolic activity in clinical applications, such as the study of severe brain injury and disorders of consciousness.

OBJECTIVE: We assessed the possibility of creating functional MRI activity maps, which could estimate the relative levels of activity in FDG-PET cerebral metabolic maps. If no metabolic absolute measures can be extracted, our approach may still be of clinical use in centers without access to FDG-PET. It also overcomes the problem of recognizing individual networks of independent component selection in functional magnetic resonance imaging (fMRI) resting state analysis.

METHODS: We extracted resting state fMRI functional connectivity maps using independent component analysis and combined only components of neuronal origin. To assess neuronality of components a classification based on support vector machine (SVM) was used. We compared the generated maps with the FDG-PET maps in 16 healthy controls, 11 vegetative state/unresponsive wakefulness syndrome patients and four locked-in patients.

RESULTS: The results show a significant similarity with ρ = 0.75 ± 0.05 for healthy controls and ρ = 0.58 ± 0.09 for vegetative state/unresponsive wakefulness syndrome patients between the FDG-PET and the fMRI based maps. FDG-PET, fMRI neuronal maps, and the conjunction analysis show decreases in frontoparietal and medial regions in vegetative patients with respect to controls. Subsequent analysis in locked-in syndrome patients produced also consistent maps with healthy controls.

CONCLUSIONS: The constructed resting state fMRI functional connectivity map points toward the possibility for fMRI resting state to estimate relative levels of activity in a metabolic map.

Notes

Open copy of article available at: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/brb3.424

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