Propofol-Induced Frontal Cortex Disconnection: A Study of Resting-State Networks, Total Brain Connectivity, and Mean BOLD Signal Oscillation Frequencies.

Authors

Pieter Guldenmund
Ithabi S Gantner
Katherine Baquero
Tushar Das
Athena Demertzi
Pierre Boveroux
Vincent Bonhomme
Audrey Vanhaudenhuyse
Marie-Aurélie Bruno
Olivia Gosseries
Quentin Noirhomme
Muriëlle Kirsch
Mélanie Boly
Adrian M Owen
Steven Laureys
Francisco Gómez
Andrea Soddu

Document Type

Article

Publication Date

4-1-2016

Journal

Brain Connect

Volume

6

Issue

3

First Page

225

Last Page

237

URL with Digital Object Identifier

10.1089/brain.2015.0369

Abstract

Propofol is one of the most commonly used anesthetics in the world, but much remains unknown about the mechanisms by which it induces loss of consciousness. In this resting-state functional magnetic resonance imaging study, we examined qualitative and quantitative changes of resting-state networks (RSNs), total brain connectivity, and mean oscillation frequencies of the regional blood oxygenation level-dependent (BOLD) signal, associated with propofol-induced mild sedation and loss of responsiveness in healthy subjects. We found that detectability of RSNs diminished significantly with loss of responsiveness, and total brain connectivity decreased strongly in the frontal cortex, which was associated with increased mean oscillation frequencies of the BOLD signal. Our results suggest a pivotal role of the frontal cortex in propofol-induced loss of responsiveness.

Notes

Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/10.1089/brain.2015.0369