Cortical folding and the potential for prognostic neuroimaging in schizophrenia

Authors

Shuixia Guo, Hunan Normal University
Sarina Iwabuchi, University of Nottingham
Vijender Balain, Penticton Regional Hospital
Jianfeng Feng, Faculty of Science, Engineering and Medicine
Peter Liddle, University of Nottingham
Lena Palaniyappan, University of Nottingham

Document Type

Article

Publication Date

11-1-2015

Journal

British Journal of Psychiatry

Volume

207

Issue

5

First Page

458

Last Page

459

URL with Digital Object Identifier

10.1192/bjp.bp.114.155796

Abstract

In 41 patients with schizophrenia, we used neuroanatomical information derived from structural imaging to identify patients with more severe illness, characterised by high symptom burden, low processing speed, high degree of illness persistence and lower social and occupational functional capacity. Cortical folding, but not thickness or volume, showed a high discriminatory ability in correctly identifying patients with more severe illness.