Bone and Joint Institute

Title

Phosphonium hydrogels for controlled release of ionic cargo

Document Type

Article

Publication Date

1-1-2018

Journal

Chemical Communications

Volume

54

Issue

79

First Page

11164

Last Page

11167

URL with Digital Object Identifier

10.1039/c8cc05083j

Abstract

© 2018 The Royal Society of Chemistry. We describe the synthesis of three different phosphonium salts and their reaction with poly(ethylene glycol) dimethacrylate to create cationic hydrogels. The hydrogels were loaded with an anionic dye and an anionic anti-inflammatory drug through ionic interactions and compared with an analogous ammonium gel. The release rates of these anions depended on their structure and pKa values, as well as the pH and ionic strength of the release medium.

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