Bone and Joint Institute
Phosphonium hydrogels for controlled release of ionic cargo
Document Type
Article
Publication Date
1-1-2018
Journal
Chemical Communications
Volume
54
Issue
79
First Page
11164
Last Page
11167
URL with Digital Object Identifier
10.1039/c8cc05083j
Abstract
© 2018 The Royal Society of Chemistry. We describe the synthesis of three different phosphonium salts and their reaction with poly(ethylene glycol) dimethacrylate to create cationic hydrogels. The hydrogels were loaded with an anionic dye and an anionic anti-inflammatory drug through ionic interactions and compared with an analogous ammonium gel. The release rates of these anions depended on their structure and pKa values, as well as the pH and ionic strength of the release medium.
Notes
Also available at https://ir.lib.uwo.ca/chempub/133/